Mitochondrial and microsomal lipid peroxidation in rat liver after acute acetaldehyde and ethanol intoxication.
J Appl Toxicol
; 9(3): 155-8, 1989 Jun.
Article
in En
| MEDLINE
| ID: mdl-2745923
ABSTRACT
The effects of acetaldehyde and ethanol treatments on hepatic lipid peroxidation are compared in rats after the administration of toxically corresponding doses. Wistar rats were given a single dose of acetaldehyde (0.5 g/kg) or ethanol (5 g/kg) intraperitoneally. The animals were killed 1/2, 1, 2, 4, 6, 9, 12 and 24 h after treatments. The results indicate that acetaldehyde, like ethanol, stimulates hepatic lipid peroxidation and also selectively affects the hepatic mitochondria.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Microsomes, Liver
/
Mitochondria, Liver
/
Lipid Peroxidation
/
Alcoholic Intoxication
/
Acetaldehyde
Limits:
Animals
Language:
En
Journal:
J Appl Toxicol
Year:
1989
Document type:
Article
Affiliation country:
Turkey
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM