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Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling.
Dobbins, Jessica; Gagnon, Etienne; Godec, Jernej; Pyrdol, Jason; Vignali, Dario A A; Sharpe, Arlene H; Wucherpfennig, Kai W.
Affiliation
  • Dobbins J; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Program in Immunology, Harvard Medical School, Boston, MA 02115, USA.
  • Gagnon E; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Godec J; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA. Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Pyrdol J; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Vignali DA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA.
  • Sharpe AH; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA. Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Wucherpfennig KW; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Program in Immunology, Harvard Medical School, Boston, MA 02115, USA. Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. kai_wucherpfennig@dfci.harvard.edu.
Sci Signal ; 9(438): ra75, 2016 07 26.
Article in En | MEDLINE | ID: mdl-27460989
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Cell Membrane / T-Lymphocytes, Regulatory / CD28 Antigens / Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Limits: Animals / Humans Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2016 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Cell Membrane / T-Lymphocytes, Regulatory / CD28 Antigens / Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Limits: Animals / Humans Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2016 Document type: Article Affiliation country: United States Country of publication: United States