Your browser doesn't support javascript.
loading
Tissue-based quantitative proteome analysis of human hepatocellular carcinoma using tandem mass tags.
Megger, Dominik Andre; Rosowski, Kristin; Ahrens, Maike; Bracht, Thilo; Eisenacher, Martin; Schlaak, Jörg F; Weber, Frank; Hoffmann, Andreas-Claudius; Meyer, Helmut E; Baba, Hideo A; Sitek, Barbara.
Affiliation
  • Megger DA; a Medizinisches Proteom-Center, Ruhr-Universität Bochum , Germany.
  • Rosowski K; a Medizinisches Proteom-Center, Ruhr-Universität Bochum , Germany.
  • Ahrens M; a Medizinisches Proteom-Center, Ruhr-Universität Bochum , Germany.
  • Bracht T; a Medizinisches Proteom-Center, Ruhr-Universität Bochum , Germany.
  • Eisenacher M; a Medizinisches Proteom-Center, Ruhr-Universität Bochum , Germany.
  • Schlaak JF; b Department of Gastroenterology and Hepatology , University Hospital of Essen , Germany.
  • Weber F; c Department of General, Visceral and Transplantation Surgery , University Hospital of Essen , Germany.
  • Hoffmann AC; d Department of Medicine (Cancer Research), Molecular Oncology Risk-Profile Evaluation , University Hospital of Essen , Germany.
  • Meyer HE; a Medizinisches Proteom-Center, Ruhr-Universität Bochum , Germany.
  • Baba HA; e Department of Pathology , University Hospital of Essen , Germany.
  • Sitek B; a Medizinisches Proteom-Center, Ruhr-Universität Bochum , Germany.
Biomarkers ; 22(2): 113-122, 2017 Mar.
Article in En | MEDLINE | ID: mdl-27467182
ABSTRACT
CONTEXT AND

OBJECTIVE:

Human hepatocellular carcinoma (HCC) is a severe malignant disease, and accurate and reliable diagnostic markers are still needed. This study was aimed for the discovery of novel marker candidates by quantitative proteomics. METHODS AND

RESULTS:

Proteomic differences between HCC and nontumorous liver tissue were studied by mass spectrometry. Among several significantly upregulated proteins, translocator protein 18 (TSPO) and Ras-related protein Rab-1A (RAB1A) were selected for verification by immunohistochemistry in an independent cohort. For RAB1A, a high accuracy for the discrimination of HCC and nontumorous liver tissue was observed.

CONCLUSION:

RAB1A was verified to be a potent biomarker candidate for HCC.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Proteome / Tandem Mass Spectrometry / Liver Neoplasms Limits: Humans Language: En Journal: Biomarkers Journal subject: BIOQUIMICA Year: 2017 Document type: Article Affiliation country: Germany
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Proteome / Tandem Mass Spectrometry / Liver Neoplasms Limits: Humans Language: En Journal: Biomarkers Journal subject: BIOQUIMICA Year: 2017 Document type: Article Affiliation country: Germany