FOXP2 Expression in Frontotemporal Lobar Degeneration-Tau.
J Alzheimers Dis
; 54(2): 471-5, 2016 09 06.
Article
in En
| MEDLINE
| ID: mdl-27497476
FOXP2 is altered in a variety of language disorders. We found reduced mRNA and protein expression of FOXP2 in frontal cortex area 8 in Pick's disease, and frontotemporal lobar degeneration-tau linked to P301L mutation presenting with language impairment in comparison with age-matched controls and cases with parkinsonian variant progressive supranuclear palsy. Foxp2 mRNA and protein are also reduced with disease progression in the somatosensory cortex in transgenic mice bearing the P301S mutation in MAPT when compared with wild-type littermates. Our findings support the presence of FOXP2 expression abnormalities in sporadic and familial frontotemporal degeneration tauopathies.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tau Proteins
/
Forkhead Transcription Factors
/
Frontotemporal Dementia
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
J Alzheimers Dis
Journal subject:
GERIATRIA
/
NEUROLOGIA
Year:
2016
Document type:
Article
Affiliation country:
Spain
Country of publication:
Netherlands