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Human and Mouse Brown Adipose Tissue Mitochondria Have Comparable UCP1 Function.
Porter, Craig; Herndon, David N; Chondronikola, Maria; Chao, Tony; Annamalai, Palam; Bhattarai, Nisha; Saraf, Manish K; Capek, Karel D; Reidy, Paul T; Daquinag, Alexes C; Kolonin, Mikhail G; Rasmussen, Blake B; Borsheim, Elisabet; Toliver-Kinsky, Tracy; Sidossis, Labros S.
Affiliation
  • Porter C; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA; Shriners Hospitals for Children, Galveston, Galveston, TX 77550, USA. Electronic address: cr2porte@utmb.edu.
  • Herndon DN; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA; Shriners Hospitals for Children, Galveston, Galveston, TX 77550, USA.
  • Chondronikola M; Department of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA; Shriners Hospitals for Children, Galveston, Galveston, TX 77550, USA.
  • Chao T; Department of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA; Shriners Hospitals for Children, Galveston, Galveston, TX 77550, USA.
  • Annamalai P; Department of Radiology, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Bhattarai N; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA; Shriners Hospitals for Children, Galveston, Galveston, TX 77550, USA.
  • Saraf MK; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA; Shriners Hospitals for Children, Galveston, Galveston, TX 77550, USA.
  • Capek KD; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA; Shriners Hospitals for Children, Galveston, Galveston, TX 77550, USA.
  • Reidy PT; Department of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Daquinag AC; The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Kolonin MG; The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Rasmussen BB; Department of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Borsheim E; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Toliver-Kinsky T; Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Sidossis LS; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA; Shriners Hospitals for Children, Galveston, Galveston, TX 77550, USA.
Cell Metab ; 24(2): 246-55, 2016 08 09.
Article in En | MEDLINE | ID: mdl-27508873
ABSTRACT
Brown adipose tissue (BAT) plays an important role in mammalian thermoregulation. The component of BAT mitochondria that permits this function is the inner membrane carrier protein uncoupling protein 1 (UCP1). To the best of our knowledge, no studies have directly quantified UCP1 function in human BAT. Further, whether human and rodent BAT have comparable thermogenic function remains unknown. We employed high-resolution respirometry to determine the respiratory capacity, coupling control, and, most importantly, UCP1 function of human supraclavicular BAT and rodent interscapular BAT. Human BAT was sensitive to the purine nucleotide GDP, providing the first direct evidence that human BAT mitochondria have thermogenically functional UCP1. Further, our data demonstrate that human and rodent BAT have similar UCP1 function per mitochondrion. These data indicate that human and rodent BAT are qualitatively similar in terms of UCP1 function.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adipose Tissue, Brown / Uncoupling Protein 1 / Mitochondria Limits: Animals / Humans / Male Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2016 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adipose Tissue, Brown / Uncoupling Protein 1 / Mitochondria Limits: Animals / Humans / Male Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2016 Document type: Article