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Description of a New Predictive Modeling Approach That Correlates the Risk and Associated Cost of Well-Defined Diabetes-Related Complications With Changes in Glycated Hemoglobin (HbA1c).
Fortwaengler, Kurt; Parkin, Christopher G; Neeser, Kurt; Neumann, Monika; Mast, Oliver.
Affiliation
  • Fortwaengler K; 1 Roche Diabetes Care GmbH, Mannheim, Germany.
  • Parkin CG; 2 CGParkin Communications, Inc, Boulder City, USA.
  • Neeser K; 3 LASER Analytica, Lörrach, Germany.
  • Neumann M; 3 LASER Analytica, Lörrach, Germany.
  • Mast O; 4 Roche Diagnostics GmbH, Mannheim, Germany.
J Diabetes Sci Technol ; 11(2): 315-323, 2017 03.
Article in En | MEDLINE | ID: mdl-27510441
ABSTRACT
The modeling approach described here is designed to support the development of spreadsheet-based simple predictive models. It is based on 3 pillars association of the complications with HbA1c changes, incidence of the complications, and average cost per event of the complication. For each pillar, the goal of the analysis was (1) to find results for a large diversity of populations with a focus on countries/regions, diabetes type, age, diabetes duration, baseline HbA1c value, and gender; (2) to assess the range of incidences and associations previously reported. Unlike simple predictive models, which mostly are based on only 1 source of information for each of the pillars, we conducted a comprehensive, systematic literature review. Each source found was thoroughly reviewed and only sources meeting quality expectations were considered. The approach allows avoidance of unintended use of extreme data. The user can utilize (1) one of the found sources, (2) the found range as validation for the found figures, or (3) the average of all found publications for an expedited estimate. The modeling approach is intended for use in average insulin-treated diabetes populations in which the baseline HbA1c values are within an average range (6.5% to 11.5%); it is not intended for use in individuals or unique diabetes populations (eg, gestational diabetes). Because the modeling approach only considers diabetes-related complications that are positively associated with HbA1c decreases, the costs of negatively associated complications (eg, severe hypoglycemic events) must be calculated separately.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glycated Hemoglobin / Models, Economic / Diabetes Complications Type of study: Etiology_studies / Health_economic_evaluation / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Humans Language: En Journal: J Diabetes Sci Technol Journal subject: ENDOCRINOLOGIA Year: 2017 Document type: Article Affiliation country: Germany

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glycated Hemoglobin / Models, Economic / Diabetes Complications Type of study: Etiology_studies / Health_economic_evaluation / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Humans Language: En Journal: J Diabetes Sci Technol Journal subject: ENDOCRINOLOGIA Year: 2017 Document type: Article Affiliation country: Germany