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NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.
Valerie, Nicholas C K; Hagenkort, Anna; Page, Brent D G; Masuyer, Geoffrey; Rehling, Daniel; Carter, Megan; Bevc, Luka; Herr, Patrick; Homan, Evert; Sheppard, Nina G; Stenmark, Pål; Jemth, Ann-Sofie; Helleday, Thomas.
Affiliation
  • Valerie NC; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Hagenkort A; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Page BD; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Masuyer G; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
  • Rehling D; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
  • Carter M; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
  • Bevc L; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Herr P; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Homan E; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Sheppard NG; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Stenmark P; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden. thomas.helleday@scilifelab.se stenmark@dbb.su.se annsofie.jemth@scilifelab.se.
  • Jemth AS; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. thomas.helleday@scilifelab.se stenmark@dbb.su.se annsofie.jemth@scilifelab.se.
  • Helleday T; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. thomas.helleday@scilifelab.se stenmark@dbb.su.se annsofie.jemth@scilifelab.se.
Cancer Res ; 76(18): 5501-11, 2016 09 15.
Article in En | MEDLINE | ID: mdl-27530327
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrophosphatases / Thioguanine / Antimetabolites, Antineoplastic Limits: Humans Language: En Journal: Cancer Res Year: 2016 Document type: Article Affiliation country: Sweden
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrophosphatases / Thioguanine / Antimetabolites, Antineoplastic Limits: Humans Language: En Journal: Cancer Res Year: 2016 Document type: Article Affiliation country: Sweden