Clinical features and management of multifocal hepatic hemangiomas in children: a retrospective study.
Sci Rep
; 6: 31744, 2016 08 17.
Article
in En
| MEDLINE
| ID: mdl-27530723
ABSTRACT
Multifocal hepatic hemangioma (MHH) is a benign hepatic tumor that is commonly diagnosed in children with multiple cutaneous infantile hemangiomas (IHs). We present a review of all children with MHH at our institutions. Of the 42 patients, the median age at presentation of MHH was 2.5 months. Thirty-six (85.7%) patients had cutaneous IHs. Twelve (28.6%) patients were symptomatic at presentation. There was no significant association between the number of hepatic hemangiomas and the number of cutaneous IHs. Fourteen (33.3%) patients received some form of treatment for hepatic hemangiomas. The most common type of treatment was oral prednisone in 8 patients, followed by oral propranolol in 6 patients. Two patients were totally resistant to prednisone treatment. They died from congestive heart failure or respiratory distress and coagulopathy. Two patients with problematic facial IH were treated with intralesional triamcinolone injection. The remaining 26 patients were managed with imaging surveillance. On follow-up, all of the survivors had a favorable outcome. Our study suggests that the clinical features of MHH are variable. Our data emphasize the treatment strategy that aggressive treatment is indicated in symptomatic or progressive MHHs, whereas observation management of asymptomatic patients with a few small lesions is safe and appropriate.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Propranolol
/
Skin Neoplasms
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Prednisolone
/
Triamcinolone
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Hemangioma
/
Liver Neoplasms
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Child, preschool
/
Female
/
Humans
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Infant
/
Male
Language:
En
Journal:
Sci Rep
Year:
2016
Document type:
Article
Affiliation country:
China