Dialkoxycarbenes in (4 + 1) Cycloadditions: Application to the Synthesis of Carotol.
Org Lett
; 18(17): 4280-3, 2016 09 02.
Article
in En
| MEDLINE
| ID: mdl-27540758
ABSTRACT
Dialkoxycarbenes are more reactive than NHCs and participate in many reactions including a formal (4 + 1) cycloaddition with electron-deficient dienes. We have learned to control the relative stereochemistry of the newly created chiral carbons in this process and now report that, combined with a chiral auxiliary, it has been used successfully in a short and efficient synthesis of the sesquiterpene carotol.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2016
Document type:
Article
Affiliation country:
Canada