Sublingual flagellin protects against acute pneumococcal pneumonia in a TLR5-dependent and NLRC4-independent fashion.
Future Microbiol
; 11: 1167-77, 2016 09.
Article
in En
| MEDLINE
| ID: mdl-27546231
ABSTRACT
AIM:
To evaluate efficacy of sublingual flagellin to treat acute pneumonia. MATERIALS &METHODS:
Mice were treated sublingually with flagellin and challenged intranasally with a lethal dose of pneumococcus. Flagellins lacking TLR5 or NLRC4 activation domains were used to assess their contribution to protection.RESULTS:
Sublingual flagellin protected mice in a TLR5-dependent, NLRC4-independent fashion. Neutrophils were required for protection. Flagellin-stimulated lung epithelial cells recapitulated the lung's transcriptional profile suggesting they could be targeted by flagellin in vivo.CONCLUSION:
Ligation of TLR5, a pathogen recognition receptor not naturally engaged by pneumococcus, protects mice from invasive pneumonia when administered via sublingual route. This can be a highly cost-effective alternative therapy against pneumonia.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pneumonia, Pneumococcal
/
Streptococcus pneumoniae
/
Bacterial Proteins
/
Calcium-Binding Proteins
/
Toll-Like Receptor 5
/
CARD Signaling Adaptor Proteins
/
Flagellin
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Future Microbiol
Journal subject:
MICROBIOLOGIA
Year:
2016
Document type:
Article
Affiliation country:
Uruguay