Chenodeoxycholic acid requires activation of EGFR, EPAC, and Ca2+ to stimulate CFTR-dependent Cl- secretion in human colonic T84 cells.

Domingue, Jada C; Ao, Mei; Sarathy, Jayashree; Rao, Mrinalini C

Domingue, Jada C; Ao, Mei; Sarathy, Jayashree; Rao, Mrinalini C.

Affiliation

Domingue JC; Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois.
Ao M; Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois.
Sarathy J; Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois.
Rao MC; Department of Biology, Benedictine University, Lisle, Illinois.

Am J Physiol Cell Physiol ; 311(5): C777-C792, 2016 Nov 01.

Article in En | MEDLINE | ID: mdl-27558159

Subject(s)

Calcium/metabolism; Chenodeoxycholic Acid/metabolism; Chlorides/metabolism; Colon/metabolism; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism; ErbB Receptors/metabolism; Guanine Nucleotide Exchange Factors/metabolism; Cell Line, Tumor; Cell Membrane/metabolism; Chloride Channels/metabolism; Cyclic AMP/metabolism; Epithelial Cells/metabolism; Humans; Phosphatidylinositol 3-Kinases/metabolism; Signal Transduction/physiology

Key words

calcium ion; chenodeoxycholic acid; cystic fibrosis transmembrane conductance regulator; epidermal growth factor receptor; exchange protein directly activated by adenosine 3',5'-cyclic monophosphate

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chenodeoxycholic Acid / Chlorides / Calcium / Colon / Cystic Fibrosis Transmembrane Conductance Regulator / Guanine Nucleotide Exchange Factors / ErbB Receptors Limits: Humans Language: En Journal: Am J Physiol Cell Physiol Journal subject: FISIOLOGIA Year: 2016 Document type: Article Country of publication: United States

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