Abnormal plasma DNA profiles in early ovarian cancer using a non-invasive prenatal testing platform: implications for cancer screening.

Cohen, Paul A; Flowers, Nicola; Tong, Stephen; Hannan, Natalie; Pertile, Mark D; Hui, Lisa

Cohen, Paul A; Flowers, Nicola; Tong, Stephen; Hannan, Natalie; Pertile, Mark D; Hui, Lisa.

Affiliation

Cohen PA; St John of God Hospital Bendat Family Comprehensive Cancer Centre, Subiaco, Perth, Western Australia, Australia. paul.cohen@sjog.org.au.
Flowers N; School of Women's and Infants' Health, University of Western Australia, Subiaco, Perth, Western Australia, Australia. paul.cohen@sjog.org.au.
Tong S; Institute for Health Research, University of Notre Dame Australia, Fremantle, Western Australia, Australia. paul.cohen@sjog.org.au.
Hannan N; Victorian Clinical Genetics Services, Parkville, Victoria, Australia.
Pertile MD; Translational Obstetrics Group, Mercy Hospital for Women, Heidelberg, Melbourne, Victoria, Australia.
Hui L; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia.

BMC Med ; 14(1): 126, 2016 08 24.

Article in En | MEDLINE | ID: mdl-27558279

Subject(s)

Early Detection of Cancer/methods; High-Throughput Nucleotide Sequencing/methods; Ovarian Neoplasms; Adult; Aged; Case-Control Studies; Chromosome Aberrations; Cytogenetic Analysis/methods; DNA/blood; DNA Copy Number Variations; Female; Humans; Middle Aged; Neoplasm Staging; Ovarian Neoplasms/diagnosis; Ovarian Neoplasms/genetics; Ovarian Neoplasms/pathology; Pregnancy; Prenatal Diagnosis/methods; Reproducibility of Results; Sensitivity and Specificity

Key words

Circulating tumor DNA; Copy number variations; Genomic profiling; High-grade serous carcinoma; Liquid biopsy; Low coverage sequencing; Non-invasive prenatal testing; Ovarian cancer screening

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Early Detection of Cancer / High-Throughput Nucleotide Sequencing Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Screening_studies Limits: Adult / Aged / Female / Humans / Middle aged / Pregnancy Language: En Journal: BMC Med Journal subject: MEDICINA Year: 2016 Document type: Article Affiliation country: Australia

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