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New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment.
Brullo, Chiara; Ricciarelli, Roberta; Prickaerts, Jos; Arancio, Ottavio; Massa, Matteo; Rotolo, Chiara; Romussi, Alessia; Rebosio, Claudia; Marengo, Barbara; Pronzato, Maria Adelaide; van Hagen, Britt T J; van Goethem, Nick P; D'Ursi, Pasqualina; Orro, Alessandro; Milanesi, Luciano; Guariento, Sara; Cichero, Elena; Fossa, Paola; Fedele, Ernesto; Bruno, Olga.
Affiliation
  • Brullo C; Department of Pharmacy, Section of Medicinal Chemistry, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.
  • Ricciarelli R; Department of Experimental Medicine, Section of General Pathology, School of Medical and Pharmaceutical Sciences, University of Genoa, Via L.B. Alberti, 2, 16132 Genoa, Italy.
  • Prickaerts J; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.
  • Arancio O; Department of Pathology & Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY 10032, USA.
  • Massa M; Department of Pharmacy, Section of Medicinal Chemistry, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.
  • Rotolo C; Department of Pharmacy, Section of Medicinal Chemistry, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.
  • Romussi A; Department of Pharmacy, Section of Medicinal Chemistry, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.
  • Rebosio C; Department of Pharmacy, Section of Pharmacology and Toxicology, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Cembrano, 4, 16147 Genoa, Italy.
  • Marengo B; Department of Experimental Medicine, Section of General Pathology, School of Medical and Pharmaceutical Sciences, University of Genoa, Via L.B. Alberti, 2, 16132 Genoa, Italy.
  • Pronzato MA; Department of Experimental Medicine, Section of General Pathology, School of Medical and Pharmaceutical Sciences, University of Genoa, Via L.B. Alberti, 2, 16132 Genoa, Italy.
  • van Hagen BTJ; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.
  • van Goethem NP; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.
  • D'Ursi P; Institute for Biomedical Technologies and National Research Council (ITB-CNR), Via Fratelli Cervi 93, 20090 Segrate, MI, Italy.
  • Orro A; Institute for Biomedical Technologies and National Research Council (ITB-CNR), Via Fratelli Cervi 93, 20090 Segrate, MI, Italy.
  • Milanesi L; Institute for Biomedical Technologies and National Research Council (ITB-CNR), Via Fratelli Cervi 93, 20090 Segrate, MI, Italy.
  • Guariento S; Department of Pharmacy, Section of Medicinal Chemistry, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.
  • Cichero E; Department of Pharmacy, Section of Medicinal Chemistry, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.
  • Fossa P; Department of Pharmacy, Section of Medicinal Chemistry, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.
  • Fedele E; Department of Pharmacy, Section of Pharmacology and Toxicology, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Cembrano, 4, 16147 Genoa, Italy; Center of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV, 9, 16132 Genoa, Italy.
  • Bruno O; Department of Pharmacy, Section of Medicinal Chemistry, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy. Electronic address: obruno@unige.it.
Eur J Med Chem ; 124: 82-102, 2016 Nov 29.
Article in En | MEDLINE | ID: mdl-27560284
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Morpholines / Cyclic Nucleotide Phosphodiesterases, Type 4 / Phosphodiesterase 4 Inhibitors / Imines / Memory Limits: Animals / Humans / Male Language: En Journal: Eur J Med Chem Year: 2016 Document type: Article Affiliation country: Italy
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Morpholines / Cyclic Nucleotide Phosphodiesterases, Type 4 / Phosphodiesterase 4 Inhibitors / Imines / Memory Limits: Animals / Humans / Male Language: En Journal: Eur J Med Chem Year: 2016 Document type: Article Affiliation country: Italy