Biochemical and molecular mechanisms underlying the chemopreventive efficacy of rosmarinic acid in a rat colon cancer.

Venkatachalam, Karthikkumar; Gunasekaran, Sivagami; Namasivayam, Nalini

Venkatachalam, Karthikkumar; Gunasekaran, Sivagami; Namasivayam, Nalini.

Affiliation

Venkatachalam K; Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamilnadu, India.
Gunasekaran S; Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamilnadu, India.
Namasivayam N; Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamilnadu, India. Electronic address: nalininam@yahoo.com.

Eur J Pharmacol ; 791: 37-50, 2016 Nov 15.

Article in En | MEDLINE | ID: mdl-27565219

Subject(s)

Anticarcinogenic Agents/pharmacology; Cinnamates/pharmacology; Colonic Neoplasms/metabolism; Colonic Neoplasms/pathology; Depsides/pharmacology; Animals; Apoptosis/drug effects; Body Weight/drug effects; Carcinogenesis/drug effects; Carcinogens/toxicity; Colonic Neoplasms/enzymology; Colonic Neoplasms/microbiology; Feces/microbiology; Gene Expression Regulation, Neoplastic/drug effects; Intestinal Mucosa/drug effects; Intestinal Mucosa/microbiology; Lipid Peroxidation/drug effects; RNA, Messenger/genetics; RNA, Messenger/metabolism; Rats; Tumor Suppressor Protein p53/genetics; Xenobiotics/metabolism; Rosmarinic Acid

Key words

ACF; Antioxidants; Apoptosis; Chemoprevention; DMH

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cinnamates / Anticarcinogenic Agents / Colonic Neoplasms / Depsides Limits: Animals Language: En Journal: Eur J Pharmacol Year: 2016 Document type: Article Affiliation country: India Country of publication: Netherlands

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