Chitosan Derivatives Active against Multidrug-Resistant Bacteria and Pathogenic Fungi: In Vivo Evaluation as Topical Antimicrobials.

Hoque, Jiaul; Adhikary, Utsarga; Yadav, Vikas; Samaddar, Sandip; Konai, Mohini Mohan; Prakash, Relekar Gnaneshwar; Paramanandham, Krishnamoorthy; Shome, Bibek R; Sanyal, Kaustuv; Haldar, Jayanta

Hoque, Jiaul; Adhikary, Utsarga; Yadav, Vikas; Samaddar, Sandip; Konai, Mohini Mohan; Prakash, Relekar Gnaneshwar; Paramanandham, Krishnamoorthy; Shome, Bibek R; Sanyal, Kaustuv; Haldar, Jayanta.

Affiliation

Hoque J; Chemical Biology and Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research , Jakkur, Bengaluru 560064, India.
Adhikary U; Chemical Biology and Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research , Jakkur, Bengaluru 560064, India.
Yadav V; Molecular Mycology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research , Jakkur, Bengaluru 560064, India.
Samaddar S; Chemical Biology and Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research , Jakkur, Bengaluru 560064, India.
Konai MM; Chemical Biology and Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research , Jakkur, Bengaluru 560064, India.
Prakash RG; Chemical Biology and Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research , Jakkur, Bengaluru 560064, India.
Paramanandham K; National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI) , Ramagondanahalli, Yelahanka, Bengaluru 560064, India.
Shome BR; National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI) , Ramagondanahalli, Yelahanka, Bengaluru 560064, India.
Sanyal K; Molecular Mycology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research , Jakkur, Bengaluru 560064, India.
Haldar J; Chemical Biology and Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research , Jakkur, Bengaluru 560064, India.

Mol Pharm ; 13(10): 3578-3589, 2016 10 03.

Article in En | MEDLINE | ID: mdl-27589087

Subject(s)

Anti-Infective Agents/therapeutic use; Chitosan/analogs & derivatives; Quaternary Ammonium Compounds/chemistry; Quaternary Ammonium Compounds/therapeutic use; Animals; Anti-Infective Agents/administration & dosage; Anti-Infective Agents/adverse effects; Cell Survival/drug effects; Chitosan/adverse effects; Chitosan/chemistry; Chitosan/therapeutic use; Drug Resistance, Fungal; Drug Resistance, Multiple, Bacterial; Female; Humans; Methicillin-Resistant Staphylococcus aureus/drug effects; Methicillin-Resistant Staphylococcus aureus/pathogenicity; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Quaternary Ammonium Compounds/adverse effects; Staphylococcal Skin Infections/drug therapy; Structure-Activity Relationship

Key words

antimicrobial polymer; antimicrobial resistance; cationic chitosan derivatives; drug-sensitive and drug-resistant bacteria; pathogenic fungi; topical infection

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Collection: 01-internacional Database: MEDLINE Main subject: Chitosan / Quaternary Ammonium Compounds / Anti-Infective Agents Limits: Animals / Female / Humans Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2016 Document type: Article Affiliation country: India

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