Feasibility of real-time near-infrared indocyanine green fluorescence endoscopy for the evaluation of mucosal head and neck lesions.
Head Neck
; 39(2): 234-240, 2017 02.
Article
in En
| MEDLINE
| ID: mdl-27590351
ABSTRACT
BACKGROUND:
The purpose of this study was to explore the feasibility and potential drawbacks of near-infrared (NIR) endoscopy with indocyanine green (ICG) to examine mucosal head and neck lesions.METHODS:
NIR ICG endoscopy was applied to image head and neck cancer epithelium in vivo. The evaluation of the ICG videos was performed off-line independently by 2 evaluators and blinded with respect to final histopathological results from biopsies taken as the gold standard.RESULTS:
Forty percent of the lesions from 55 patients were histologically malignant. ICG positivity showed a sensitivity, specificity, and accuracy to be related to a malignant tumor of 90.5%, 90.9%, and 89.1%, respectively. The kappa index for the interobserver assessment showed a 94.4% agreement for the assessment of the ICG positivity. Side effects of the NIR ICG endoscopy did not arise.CONCLUSION:
NIR ICG endoscopy in patients with mucosal head and neck lesions was feasible and safe. It might help intraoperatively to differentiate benign from malignant lesions. © 2016 Wiley Periodicals, Inc. Head Neck 39 234-240, 2017.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spectroscopy, Near-Infrared
/
Head and Neck Neoplasms
/
Indocyanine Green
/
Laryngoscopy
Type of study:
Diagnostic_studies
/
Observational_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Head Neck
Journal subject:
NEOPLASIAS
Year:
2017
Document type:
Article
Affiliation country:
Germany