Resveratrol protects against lipopolysaccharide-induced cardiac dysfunction by enhancing SERCA2a activity through promoting the phospholamban oligomerization.

Bai, Tao; Hu, Xinyue; Zheng, Yang; Wang, Shudong; Kong, Jian; Cai, Lu

Bai, Tao; Hu, Xinyue; Zheng, Yang; Wang, Shudong; Kong, Jian; Cai, Lu.

Affiliation

Bai T; Cardiovascular Center, First Hospital of Jilin University, Changchun, China; Departments of Pediatrics and Radiation Oncology, Kosair Children's Hospital Research Institute, University of Louisville, Louisville, Kentucky.
Hu X; Cardiovascular Center, First Hospital of Jilin University, Changchun, China; Departments of Pediatrics and Radiation Oncology, Kosair Children's Hospital Research Institute, University of Louisville, Louisville, Kentucky.
Zheng Y; Cardiovascular Center, First Hospital of Jilin University, Changchun, China.
Wang S; Cardiovascular Center, First Hospital of Jilin University, Changchun, China; Departments of Pediatrics and Radiation Oncology, Kosair Children's Hospital Research Institute, University of Louisville, Louisville, Kentucky.
Kong J; Department of Geriatric Medicine, First Hospital of Jilin University, Changchun, China; and kongjian_2015@163.com.
Cai L; Departments of Pediatrics and Radiation Oncology, Kosair Children's Hospital Research Institute, University of Louisville, Louisville, Kentucky.

Am J Physiol Heart Circ Physiol ; 311(4): H1051-H1062, 2016 10 01.

Article in En | MEDLINE | ID: mdl-27591219

Subject(s)

Antioxidants/pharmacology; Calcium-Binding Proteins/drug effects; Heart/drug effects; Lipopolysaccharides/pharmacology; Myocardial Contraction/drug effects; Myocytes, Cardiac/drug effects; Sarcoplasmic Reticulum Calcium-Transporting ATPases/drug effects; Stilbenes/pharmacology; Aldehydes/metabolism; Animals; Blotting, Western; Calcium/metabolism; Calcium-Binding Proteins/metabolism; Down-Regulation; Immunoblotting; Male; Malondialdehyde/metabolism; Mice; Mice, Inbred C57BL; Myocardium/metabolism; Myocytes, Cardiac/metabolism; NF-E2-Related Factor 2/drug effects; NF-E2-Related Factor 2/metabolism; Oxidative Stress/drug effects; Polymers/metabolism; Resveratrol; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism; Superoxides/metabolism; Troponin I/drug effects; Troponin I/metabolism; Tumor Necrosis Factor-alpha/drug effects; Tumor Necrosis Factor-alpha/metabolism; Up-Regulation

Key words

heart failure; nuclear factor (erythroid-derived 2)-like 2; sarcoplasmic endoplasmic reticulum calcium ion-ATPase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stilbenes / Calcium-Binding Proteins / Lipopolysaccharides / Myocytes, Cardiac / Sarcoplasmic Reticulum Calcium-Transporting ATPases / Heart / Myocardial Contraction / Antioxidants Limits: Animals Language: En Journal: Am J Physiol Heart Circ Physiol Journal subject: CARDIOLOGIA / FISIOLOGIA Year: 2016 Document type: Article

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