Pharmacokinetic interaction in beagle dogs of antiplatelet drugs: acetylsalicylic acid, dipyridamole and calcium dobesilate.
Eur J Drug Metab Pharmacokinet
; 14(1): 79-83, 1989.
Article
in En
| MEDLINE
| ID: mdl-2759138
ABSTRACT
In clinical practice, the co-administration of antiplatelet drugs, such as acetylsalicylic acid (ASA) and dipyridamole (DP) and calcium dobesilate, is often recommended in order to obtain secondary prophylaxis against certain ischaemic diseases. Therefore the possible pharmacokinetic interactions between these three drugs were studied after a single-dose in beagle dogs. The plasma concentrations of ASA, DP and CaDb were measured by HPLC. It was found that the DP and CaDb kinetics were unaffected by concurrent intake of ASA, DP or CaDb. However, concurrent DP or CaDb improved the bioavailability of ASA, particularly the increased Cmax and (AUC).
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzenesulfonates
/
Calcium Dobesilate
/
Platelet Aggregation Inhibitors
/
Aspirin
/
Dipyridamole
Limits:
Animals
Language:
En
Journal:
Eur J Drug Metab Pharmacokinet
Year:
1989
Document type:
Article
Affiliation country:
Greece