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In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling.
Bulley, Simon J; Droubi, Alaa; Clarke, Jonathan H; Anderson, Karen E; Stephens, Len R; Hawkins, Phillip T; Irvine, Robin F.
Affiliation
  • Bulley SJ; Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom;
  • Droubi A; Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom;
  • Clarke JH; Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom;
  • Anderson KE; Inositide Laboratory, Babraham Institute, Cambridge CB22 4AT, United Kingdom.
  • Stephens LR; Inositide Laboratory, Babraham Institute, Cambridge CB22 4AT, United Kingdom.
  • Hawkins PT; Inositide Laboratory, Babraham Institute, Cambridge CB22 4AT, United Kingdom.
  • Irvine RF; Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom; rfi20@cam.ac.uk.
Proc Natl Acad Sci U S A ; 113(38): 10571-6, 2016 09 20.
Article in En | MEDLINE | ID: mdl-27601656
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphotransferases / Phosphatidylinositol Phosphates / Proto-Oncogene Proteins c-akt / Mechanistic Target of Rapamycin Complex 2 Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphotransferases / Phosphatidylinositol Phosphates / Proto-Oncogene Proteins c-akt / Mechanistic Target of Rapamycin Complex 2 Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Document type: Article