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Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients.
Takatsuki, Hanae; Fuse, Takayuki; Nakagaki, Takehiro; Mori, Tsuyoshi; Mihara, Ban; Takao, Masaki; Iwasaki, Yasushi; Yoshida, Mari; Murayama, Shigeo; Atarashi, Ryuichiro; Nishida, Noriyuki; Satoh, Katsuya.
Affiliation
  • Takatsuki H; Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  • Fuse T; Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  • Nakagaki T; Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  • Mori T; Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
  • Mihara B; Department of Neurology, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Isesaki, Japan.
  • Takao M; Department of Neurology, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Isesaki, Japan; Department of Neurology International Medical Center, Saitama Medical University, Saitama, Japan.
  • Iwasaki Y; Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Aichi, Japan.
  • Yoshida M; Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Aichi, Japan.
  • Murayama S; Department of Neuropathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
  • Atarashi R; Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
  • Nishida N; Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  • Satoh K; Department of Locomotive Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. Electronic address: satoh-prion@nagasaki-u.ac.jp.
EBioMedicine ; 12: 150-155, 2016 Oct.
Article in En | MEDLINE | ID: mdl-27612591
ABSTRACT
Human prion diseases are neurodegenerative disorders caused by abnormally folded prion proteins in the central nervous system. These proteins can be detected using the quaking-induced conversion assay. Compared with other bioassays, this assay is extremely sensitive and was used in the present study to determine prion distribution in sporadic Creutzfeldt-Jakob disease patients at autopsy. Although infectivity of the sporadic form is thought to be restricted within the central nervous system, results showed that prion-seeding activities reach 106/g from a 50% seeding dose in non-neuronal tissues, suggesting that prion-seeding activity exists in non-neural organs, and we suggested that non-neural tissues of 106/g SD50 did not exist the infectivity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Creutzfeldt-Jakob Syndrome / Prion Proteins Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies Limits: Aged / Animals / Female / Humans / Middle aged Language: En Journal: EBioMedicine Year: 2016 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Creutzfeldt-Jakob Syndrome / Prion Proteins Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies Limits: Aged / Animals / Female / Humans / Middle aged Language: En Journal: EBioMedicine Year: 2016 Document type: Article Affiliation country: Japan