Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients.
EBioMedicine
; 12: 150-155, 2016 Oct.
Article
in En
| MEDLINE
| ID: mdl-27612591
ABSTRACT
Human prion diseases are neurodegenerative disorders caused by abnormally folded prion proteins in the central nervous system. These proteins can be detected using the quaking-induced conversion assay. Compared with other bioassays, this assay is extremely sensitive and was used in the present study to determine prion distribution in sporadic Creutzfeldt-Jakob disease patients at autopsy. Although infectivity of the sporadic form is thought to be restricted within the central nervous system, results showed that prion-seeding activities reach 106/g from a 50% seeding dose in non-neuronal tissues, suggesting that prion-seeding activity exists in non-neural organs, and we suggested that non-neural tissues of 106/g SD50 did not exist the infectivity.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Creutzfeldt-Jakob Syndrome
/
Prion Proteins
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Aged
/
Animals
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
EBioMedicine
Year:
2016
Document type:
Article
Affiliation country:
Japan