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Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution.
Hayes, Angela; Mok, N Yi; Liu, Manjuan; Thai, Ching; Henley, Alan T; Atrash, Butrus; Lanigan, Rachel M; Sejberg, Jemmy; Le Bihan, Yann-Vaï; Bavetsias, Vassilios; Blagg, Julian; Raynaud, Florence I.
Affiliation
  • Hayes A; a Cancer Research UK Cancer Therapeutics Unit , The Institute of Cancer Research , London , UK.
  • Mok NY; a Cancer Research UK Cancer Therapeutics Unit , The Institute of Cancer Research , London , UK.
  • Liu M; a Cancer Research UK Cancer Therapeutics Unit , The Institute of Cancer Research , London , UK.
  • Thai C; a Cancer Research UK Cancer Therapeutics Unit , The Institute of Cancer Research , London , UK.
  • Henley AT; a Cancer Research UK Cancer Therapeutics Unit , The Institute of Cancer Research , London , UK.
  • Atrash B; a Cancer Research UK Cancer Therapeutics Unit , The Institute of Cancer Research , London , UK.
  • Lanigan RM; a Cancer Research UK Cancer Therapeutics Unit , The Institute of Cancer Research , London , UK.
  • Sejberg J; a Cancer Research UK Cancer Therapeutics Unit , The Institute of Cancer Research , London , UK.
  • Le Bihan YV; a Cancer Research UK Cancer Therapeutics Unit , The Institute of Cancer Research , London , UK.
  • Bavetsias V; a Cancer Research UK Cancer Therapeutics Unit , The Institute of Cancer Research , London , UK.
  • Blagg J; a Cancer Research UK Cancer Therapeutics Unit , The Institute of Cancer Research , London , UK.
  • Raynaud FI; a Cancer Research UK Cancer Therapeutics Unit , The Institute of Cancer Research , London , UK.
Xenobiotica ; 47(9): 771-777, 2017 Sep.
Article in En | MEDLINE | ID: mdl-27618572
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Aldehyde Oxidase Limits: Animals / Humans Language: En Journal: Xenobiotica Year: 2017 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom
Fulltext
Add to My VHL
Print
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Aldehyde Oxidase Limits: Animals / Humans Language: En Journal: Xenobiotica Year: 2017 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom