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High-throughput discovery of novel developmental phenotypes.
Dickinson, Mary E; Flenniken, Ann M; Ji, Xiao; Teboul, Lydia; Wong, Michael D; White, Jacqueline K; Meehan, Terrence F; Weninger, Wolfgang J; Westerberg, Henrik; Adissu, Hibret; Baker, Candice N; Bower, Lynette; Brown, James M; Caddle, L Brianna; Chiani, Francesco; Clary, Dave; Cleak, James; Daly, Mark J; Denegre, James M; Doe, Brendan; Dolan, Mary E; Edie, Sarah M; Fuchs, Helmut; Gailus-Durner, Valerie; Galli, Antonella; Gambadoro, Alessia; Gallegos, Juan; Guo, Shiying; Horner, Neil R; Hsu, Chih-Wei; Johnson, Sara J; Kalaga, Sowmya; Keith, Lance C; Lanoue, Louise; Lawson, Thomas N; Lek, Monkol; Mark, Manuel; Marschall, Susan; Mason, Jeremy; McElwee, Melissa L; Newbigging, Susan; Nutter, Lauryl M J; Peterson, Kevin A; Ramirez-Solis, Ramiro; Rowland, Douglas J; Ryder, Edward; Samocha, Kaitlin E; Seavitt, John R; Selloum, Mohammed; Szoke-Kovacs, Zsombor.
Affiliation
  • Dickinson ME; Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA.
  • Flenniken AM; The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada.
  • Ji X; Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
  • Teboul L; Genomics and Computational Biology Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
  • Wong MD; Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.
  • White JK; The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada.
  • Meehan TF; Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario M5T 3H7, Canada.
  • Weninger WJ; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Westerberg H; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Adissu H; Centre for Anatomy and Cell Biology, Medical University of Vienna, Vienna A-1090, Austria.
  • Baker CN; Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.
  • Bower L; The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada.
  • Brown JM; The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Caddle LB; The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
  • Chiani F; Mouse Biology Program, University of California, Davis, California 95618, USA.
  • Clary D; Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.
  • Cleak J; The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
  • Daly MJ; Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo I-00015, Italy.
  • Denegre JM; Mouse Biology Program, University of California, Davis, California 95618, USA.
  • Doe B; Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.
  • Dolan ME; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
  • Edie SM; Program in Medical and Population Genetics, Broad Institute MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Fuchs H; The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
  • Gailus-Durner V; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Galli A; The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
  • Gambadoro A; The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
  • Gallegos J; Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764, Germany.
  • Guo S; Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764, Germany.
  • Horner NR; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Hsu CW; Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo I-00015, Italy.
  • Johnson SJ; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
  • Kalaga S; SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, Nanjing 210061, China.
  • Keith LC; Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.
  • Lanoue L; Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA.
  • Lawson TN; Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.
  • Lek M; Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA.
  • Mark M; Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA.
  • Marschall S; Mouse Biology Program, University of California, Davis, California 95618, USA.
  • Mason J; Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK.
  • McElwee ML; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
  • Newbigging S; Program in Medical and Population Genetics, Broad Institute MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Nutter LM; Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), et Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, University of Strasbourg, Illkirch-Graffenstaden 67404, France.
  • Peterson KA; Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg 85764, Germany.
  • Ramirez-Solis R; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Rowland DJ; Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA.
  • Ryder E; The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada.
  • Samocha KE; The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Seavitt JR; The Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada.
  • Selloum M; The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Szoke-Kovacs Z; The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Nature ; 537(7621): 508-514, 2016 09 22.
Article in En | MEDLINE | ID: mdl-27626380
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenotype / Genes, Essential / Embryo, Mammalian / Genes, Lethal / Mutation Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nature Year: 2016 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenotype / Genes, Essential / Embryo, Mammalian / Genes, Lethal / Mutation Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nature Year: 2016 Document type: Article Affiliation country: United States