Administration of Non-Torsadogenic human Ether-à-go-go-Related Gene Inhibitors Is Associated with Better Survival for High hERG-Expressing Glioblastoma Patients.

Pointer, Kelli B; Clark, Paul A; Eliceiri, Kevin W; Salamat, M Shahriar; Robertson, Gail A; Kuo, John S

Pointer, Kelli B; Clark, Paul A; Eliceiri, Kevin W; Salamat, M Shahriar; Robertson, Gail A; Kuo, John S.

Affiliation

Pointer KB; Department of Neurological Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.
Clark PA; Medical Scientist Training Program, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.
Eliceiri KW; Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, Wisconsin.
Salamat MS; Laboratory for Optical and Computational Instrumentation (LOCI), University of Wisconsin-Madison, Madison, Wisconsin.
Robertson GA; Department of Neurological Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.
Kuo JS; Laboratory for Optical and Computational Instrumentation (LOCI), University of Wisconsin-Madison, Madison, Wisconsin.

Clin Cancer Res ; 23(1): 73-80, 2017 Jan 01.

Article in En | MEDLINE | ID: mdl-27635088

Subject(s)

Antineoplastic Agents/administration & dosage; Brain Neoplasms/metabolism; Brain Neoplasms/mortality; Ether-A-Go-Go Potassium Channels/antagonists & inhibitors; Ether-A-Go-Go Potassium Channels/metabolism; Glioblastoma/metabolism; Glioblastoma/mortality; Piperidines/administration & dosage; Pyridines/administration & dosage; Animals; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Brain Neoplasms/diagnosis; Brain Neoplasms/drug therapy; Cell Proliferation/drug effects; Disease Models, Animal; Ether-A-Go-Go Potassium Channels/genetics; Gene Expression; Glioblastoma/diagnosis; Glioblastoma/drug therapy; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Mice; Molecular Targeted Therapy; Spheroids, Cellular; Tissue Array Analysis; Tumor Burden/drug effects; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Pyridines / Brain Neoplasms / Glioblastoma / Ether-A-Go-Go Potassium Channels / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2017 Document type: Article Country of publication: United States

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