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Whole-exome sequencing identifies multiple loss-of-function mutations of NF-κB pathway regulators in nasopharyngeal carcinoma.
Zheng, Hong; Dai, Wei; Cheung, Arthur Kwok Leung; Ko, Josephine Mun Yee; Kan, Rebecca; Wong, Bonnie Wing Yan; Leong, Merrin Man Long; Deng, Mingdan; Kwok, Tommy Chin Tung; Chan, Jimmy Yu-Wai; Kwong, Dora Lai-Wan; Lee, Anne Wing-Mui; Ng, Wai Tong; Ngan, Roger Kai Cheong; Yau, Chun Chung; Tung, Stewart; Lee, Victor Ho-Fun; Lam, Ka-On; Kwan, Chung Kong; Li, Wing Sum; Yau, Stephen; Chan, Kwok-Wah; Lung, Maria Li.
Affiliation
  • Zheng H; Department of Clinical Oncology, The University of Hong Kong, Hong Kong, People's Republic of China.
  • Dai W; Department of Clinical Oncology, The University of Hong Kong, Hong Kong, People's Republic of China.
  • Cheung AK; Department of Clinical Oncology, The University of Hong Kong, Hong Kong, People's Republic of China.
  • Ko JM; Department of Clinical Oncology, The University of Hong Kong, Hong Kong, People's Republic of China.
  • Kan R; Department of Clinical Oncology, The University of Hong Kong, Hong Kong, People's Republic of China.
  • Wong BW; Department of Clinical Oncology, The University of Hong Kong, Hong Kong, People's Republic of China.
  • Leong MM; Department of Clinical Oncology, The University of Hong Kong, Hong Kong, People's Republic of China.
  • Deng M; Department of Clinical Oncology, The University of Hong Kong, Hong Kong, People's Republic of China.
  • Kwok TC; Department of Clinical Oncology, The University of Hong Kong, Hong Kong, People's Republic of China.
  • Chan JY; Center for Nasopharyngeal Carcinoma Research, The University of Hong Kong, Hong Kong, People's Republic of China; Department of Surgery, The University of Hong Kong, Hong Kong, People's Republic of China.
  • Kwong DL; Department of Clinical Oncology, The University of Hong Kong, Hong Kong, People's Republic of China; Center for Nasopharyngeal Carcinoma Research, The University of Hong Kong, Hong Kong, People's Republic of China.
  • Lee AW; Department of Clinical Oncology, The University of Hong Kong, Hong Kong, People's Republic of China; Center for Nasopharyngeal Carcinoma Research, The University of Hong Kong, Hong Kong, People's Republic of China.
  • Ng WT; Center for Nasopharyngeal Carcinoma Research, The University of Hong Kong, Hong Kong, People's Republic of China; Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, People's Republic of China.
  • Ngan RK; Center for Nasopharyngeal Carcinoma Research, The University of Hong Kong, Hong Kong, People's Republic of China; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, People's Republic of China.
  • Yau CC; Center for Nasopharyngeal Carcinoma Research, The University of Hong Kong, Hong Kong, People's Republic of China; Department of Oncology, Princess Margaret Hospital, Hong Kong, People's Republic of China.
  • Tung S; Center for Nasopharyngeal Carcinoma Research, The University of Hong Kong, Hong Kong, People's Republic of China; Department of Clinical Oncology, Tuen Mun Hospital, Hong Kong, People's Republic of China.
  • Lee VH; Department of Clinical Oncology, The University of Hong Kong, Hong Kong, People's Republic of China; Center for Nasopharyngeal Carcinoma Research, The University of Hong Kong, Hong Kong, People's Republic of China.
  • Lam KO; Department of Clinical Oncology, The University of Hong Kong, Hong Kong, People's Republic of China; Center for Nasopharyngeal Carcinoma Research, The University of Hong Kong, Hong Kong, People's Republic of China.
  • Kwan CK; Center for Nasopharyngeal Carcinoma Research, The University of Hong Kong, Hong Kong, People's Republic of China; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, People's Republic of China.
  • Li WS; Center for Nasopharyngeal Carcinoma Research, The University of Hong Kong, Hong Kong, People's Republic of China; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, People's Republic of China.
  • Yau S; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, People's Republic of China.
  • Chan KW; Department of Pathology, The University of Hong Kong, Hong Kong, People's Republic of China.
  • Lung ML; Department of Clinical Oncology, The University of Hong Kong, Hong Kong, People's Republic of China; Center for Nasopharyngeal Carcinoma Research, The University of Hong Kong, Hong Kong, People's Republic of China; mlilung@hku.hk.
Proc Natl Acad Sci U S A ; 113(40): 11283-11288, 2016 10 04.
Article in En | MEDLINE | ID: mdl-27647909
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma / Signal Transduction / Nasopharyngeal Neoplasms / NF-kappa B / Exome Sequencing / Loss of Function Mutation Type of study: Prognostic_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma / Signal Transduction / Nasopharyngeal Neoplasms / NF-kappa B / Exome Sequencing / Loss of Function Mutation Type of study: Prognostic_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Document type: Article Country of publication: United States