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Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells.
Timosenko, Elina; Ghadbane, Hemza; Silk, Jonathan D; Shepherd, Dawn; Gileadi, Uzi; Howson, Lauren J; Laynes, Robert; Zhao, Qi; Strausberg, Robert L; Olsen, Lars R; Taylor, Stephen; Buffa, Francesca M; Boyd, Richard; Cerundolo, Vincenzo.
Affiliation
  • Timosenko E; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
  • Ghadbane H; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
  • Silk JD; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
  • Shepherd D; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
  • Gileadi U; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
  • Howson LJ; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
  • Laynes R; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
  • Zhao Q; Ludwig Cancer Research, New York, New York.
  • Strausberg RL; Ludwig Cancer Research, New York, New York.
  • Olsen LR; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark.
  • Taylor S; The Computational Biology Research Group (CBRG), Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
  • Buffa FM; Department of Oncology, Old Road Campus Research Building, University of Oxford, Oxford, United Kingdom.
  • Boyd R; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
  • Cerundolo V; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom. vincenzo.cerundolo@imm.ox.ac.uk.
Cancer Res ; 76(21): 6193-6204, 2016 11 01.
Article in En | MEDLINE | ID: mdl-27651314
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tryptophan / Minor Histocompatibility Antigens / Amino Acid Transport Systems / Amino Acid Transport System ASC / Indoleamine-Pyrrole 2,3,-Dioxygenase / Activating Transcription Factor 4 / Cellular Reprogramming / Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cancer Res Year: 2016 Document type: Article Affiliation country: United kingdom Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tryptophan / Minor Histocompatibility Antigens / Amino Acid Transport Systems / Amino Acid Transport System ASC / Indoleamine-Pyrrole 2,3,-Dioxygenase / Activating Transcription Factor 4 / Cellular Reprogramming / Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cancer Res Year: 2016 Document type: Article Affiliation country: United kingdom Country of publication: United States