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Nuclear envelope rupture: Actin fibers are putting the squeeze on the nucleus.
Lammerding, Jan; Wolf, Katarina.
Affiliation
  • Lammerding J; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853 jan.lammerding@cornell.edu.
  • Wolf K; Department of Cell Biology, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
J Cell Biol ; 215(1): 5-8, 2016 Oct 10.
Article in En | MEDLINE | ID: mdl-27697927
ABSTRACT
Cells exhibit transient nuclear envelope ruptures during interphase, but the responsible biophysical processes remain unclear. In this issue, Hatch and Hetzer (2016. J. Cell Biol. http//dx.doi.org/10.1083/jcb.201603053) show that actin fibers constrict the nucleus, causing chromatin protrusions and nuclear membrane ruptures at sites with nuclear lamina defects.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Actins / Nuclear Envelope Limits: Animals / Humans Language: En Journal: J Cell Biol Year: 2016 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Actins / Nuclear Envelope Limits: Animals / Humans Language: En Journal: J Cell Biol Year: 2016 Document type: Article