Dysregulation of histone methyltransferases in breast cancer - Opportunities for new targeted therapies?

Michalak, Ewa M; Visvader, Jane E

Michalak, Ewa M; Visvader, Jane E.

Affiliation

Michalak EM; ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address: michalak@wehi.edu.au.
Visvader JE; ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address: visvader@wehi.edu.au.

Mol Oncol ; 10(10): 1497-1515, 2016 12.

Article in En | MEDLINE | ID: mdl-27717710

Subject(s)

Breast Neoplasms/genetics; Breast Neoplasms/pathology; Breast/pathology; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase/genetics; Protein-Arginine N-Methyltransferases/genetics; Animals; Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Breast/drug effects; Breast Neoplasms/drug therapy; Breast Neoplasms/metabolism; Drug Discovery; Enzyme Inhibitors/pharmacology; Enzyme Inhibitors/therapeutic use; Epigenesis, Genetic/drug effects; Female; Gene Expression Regulation, Neoplastic/drug effects; Histone Code/drug effects; Histone-Lysine N-Methyltransferase/analysis; Histone-Lysine N-Methyltransferase/antagonists & inhibitors; Histone-Lysine N-Methyltransferase/metabolism; Humans; Molecular Targeted Therapy; Protein-Arginine N-Methyltransferases/analysis; Protein-Arginine N-Methyltransferases/antagonists & inhibitors; Protein-Arginine N-Methyltransferases/metabolism; Transcriptional Activation/drug effects

Key words

Breast cancer; Chromatin; Histone methyltransferase; Inhibitors; Transcription

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Arginine N-Methyltransferases / Breast / Breast Neoplasms / Gene Expression Regulation, Neoplastic / Histone-Lysine N-Methyltransferase Limits: Animals / Female / Humans Language: En Journal: Mol Oncol Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2016 Document type: Article Country of publication: United States

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