Three-dimensional reconstruction of single-cell chromosome structure using recurrence plots.
Sci Rep
; 6: 34982, 2016 10 11.
Article
in En
| MEDLINE
| ID: mdl-27725694
ABSTRACT
Single-cell analysis of the three-dimensional (3D) chromosome structure can reveal cell-to-cell variability in genome activities. Here, we propose to apply recurrence plots, a mathematical method of nonlinear time series analysis, to reconstruct the 3D chromosome structure of a single cell based on information of chromosomal contacts from genome-wide chromosome conformation capture (Hi-C) data. This recurrence plot-based reconstruction (RPR) method enables rapid reconstruction of a unique structure in single cells, even from incomplete Hi-C information.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromosomes
/
Chromosome Structures
/
Imaging, Three-Dimensional
Limits:
Animals
Language:
En
Journal:
Sci Rep
Year:
2016
Document type:
Article
Affiliation country:
Japan