ATM is the primary kinase responsible for phosphorylation of Hsp90&#945; after ionizing radiation.

Elaimy, Ameer L; Ahsan, Aarif; Marsh, Katherine; Pratt, William B; Ray, Dipankar; Lawrence, Theodore S; Nyati, Mukesh K

ATM is the primary kinase responsible for phosphorylation of Hsp90α after ionizing radiation.

Elaimy, Ameer L; Ahsan, Aarif; Marsh, Katherine; Pratt, William B; Ray, Dipankar; Lawrence, Theodore S; Nyati, Mukesh K.

Affiliation

Elaimy AL; Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Ahsan A; Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Marsh K; Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Pratt WB; Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Ray D; Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Lawrence TS; Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Nyati MK; Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

Oncotarget ; 7(50): 82450-82457, 2016 Dec 13.

Article in En | MEDLINE | ID: mdl-27738310

Subject(s)

Ataxia Telangiectasia Mutated Proteins/metabolism; Carcinoma, Squamous Cell/radiotherapy; Fibroblasts/radiation effects; HSP90 Heat-Shock Proteins/metabolism; Head and Neck Neoplasms/radiotherapy; Lung Neoplasms/radiotherapy; Animals; Carcinoma, Squamous Cell/enzymology; Carcinoma, Squamous Cell/pathology; Cell Line, Tumor; Cell Nucleus/enzymology; Cell Nucleus/pathology; Cell Nucleus/radiation effects; DNA Damage; Dose-Response Relationship, Radiation; Fibroblasts/enzymology; Fibroblasts/pathology; HSP90 Heat-Shock Proteins/genetics; Head and Neck Neoplasms/enzymology; Head and Neck Neoplasms/pathology; Histones/metabolism; Humans; Kinetics; Lung Neoplasms/enzymology; Lung Neoplasms/pathology; Mice; Phosphorylation; RNA Interference; Squamous Cell Carcinoma of Head and Neck; Time Factors; Transfection

Key words

ATM; Hsp90α; ionizing radiation; radiosensitization; Î³H2AX

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Squamous Cell / HSP90 Heat-Shock Proteins / Fibroblasts / Ataxia Telangiectasia Mutated Proteins / Head and Neck Neoplasms / Lung Neoplasms Limits: Animals / Humans Language: En Journal: Oncotarget Year: 2016 Document type: Article Affiliation country: United States

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