Invited Commentary: Hypertension During Pregnancy and Offspring Microvascular Structure-Insights From the Retinal Microcirculation.
Am J Epidemiol
; 184(9): 616-618, 2016 11 01.
Article
in En
| MEDLINE
| ID: mdl-27744389
ABSTRACT
Human clinical studies as well as laboratory animal studies demonstrate that offspring of pregnancies affected by common complications, such as preeclampsia and preterm birth, display developmental phenotypes that relate distinctly to the pregnancy disorder. Several studies have now found microvascular differences in offspring of hypertensive pregnancies, and there is interest in whether these may underlie epidemiologic associations between gestational hypertension and a higher risk of hypertension and stroke in the offspring. The retinal circulation provides a unique window into microvascular structure, of likely relevance to both the cerebrovasculature and broader cardiovascular risk. Yesil et al. (Am J Epidemiol 2016;184(9)605-615) report in this issue of the Journal that maternal gestational blood pressure elevation is associated with reduced retinal vascular caliber in offspring at 6 years of age, providing a link between variation in pregnancy characteristics and childhood vascular development. Further work to understand the longitudinal association between pregnancy, emergence of microvascular changes, and cardiovascular risk may identify opportunities for future preventive interventions.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cardiovascular Diseases
/
Microcirculation
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Am J Epidemiol
Year:
2016
Document type:
Article