Biodistribution of Idursulfase Formulated for Intrathecal Use (Idursulfase-IT) in Cynomolgus Monkeys after Intrathecal Lumbar Administration.

Chung, Jou-Ku; Brown, Eilish; Crooker, Bob; Palmieri, Kathleen J; McCauley, Thomas G

Chung, Jou-Ku; Brown, Eilish; Crooker, Bob; Palmieri, Kathleen J; McCauley, Thomas G.

Affiliation

Chung JK; Shire, Lexington, Massachusetts, United States of America.
Brown E; Shire, Lexington, Massachusetts, United States of America.
Crooker B; Shire, Lexington, Massachusetts, United States of America.
Palmieri KJ; Shire, Lexington, Massachusetts, United States of America.
McCauley TG; Shire, Lexington, Massachusetts, United States of America.

PLoS One ; 11(10): e0164765, 2016.

Article in En | MEDLINE | ID: mdl-27764180

Subject(s)

Enzyme Replacement Therapy; Iduronate Sulfatase/administration & dosage; Mucopolysaccharidosis II/drug therapy; Animals; Brain/enzymology; Drug Evaluation, Preclinical; Female; Humans; Iduronate Sulfatase/pharmacokinetics; Injections, Spinal; Kidney/enzymology; Liver/enzymology; Macaca fascicularis; Male; Spinal Cord/enzymology; Time Factors; Tissue Distribution

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mucopolysaccharidosis II / Enzyme Replacement Therapy / Iduronate Sulfatase Limits: Animals / Female / Humans / Male Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2016 Document type: Article Affiliation country: United States

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