E3 ubiquitin ligase Cbl-b activates the p53 pathway by targeting Siva1, a negative regulator of ARF, in FLT3 inhibitor-resistant acute myeloid leukemia.

Park, I-K; Blum, W; Baker, S D; Caligiuri, M A

Park, I-K; Blum, W; Baker, S D; Caligiuri, M A.

Affiliation

Park IK; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Blum W; Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Baker SD; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Caligiuri MA; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.

Leukemia ; 31(2): 502-505, 2017 02.

Article in En | MEDLINE | ID: mdl-27773928

Subject(s)

Apoptosis Regulatory Proteins/antagonists & inhibitors; Drug Resistance, Neoplasm; Leukemia, Myeloid, Acute/metabolism; Proto-Oncogene Proteins c-cbl/physiology; Humans; Signal Transduction; Tumor Suppressor Protein p53/metabolism; Ubiquitin-Protein Ligases/physiology; fms-Like Tyrosine Kinase 3/antagonists & inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Drug Resistance, Neoplasm / Proto-Oncogene Proteins c-cbl / Apoptosis Regulatory Proteins Limits: Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2017 Document type: Article Affiliation country: United States Country of publication: United kingdom

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