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Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade.
Pauken, Kristen E; Sammons, Morgan A; Odorizzi, Pamela M; Manne, Sasikanth; Godec, Jernej; Khan, Omar; Drake, Adam M; Chen, Zeyu; Sen, Debattama R; Kurachi, Makoto; Barnitz, R Anthony; Bartman, Caroline; Bengsch, Bertram; Huang, Alexander C; Schenkel, Jason M; Vahedi, Golnaz; Haining, W Nicholas; Berger, Shelley L; Wherry, E John.
Affiliation
  • Pauken KE; Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Sammons MA; Departments of Cell and Developmental Biology, Genetics, and Biology, Penn Epigenetics Program, University of Pennsylvania, Philadelphia, PA, USA.
  • Odorizzi PM; Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Manne S; Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Godec J; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Khan O; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.
  • Drake AM; Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Chen Z; Departments of Cell and Developmental Biology, Genetics, and Biology, Penn Epigenetics Program, University of Pennsylvania, Philadelphia, PA, USA.
  • Sen DR; Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Kurachi M; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Barnitz RA; Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Bartman C; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Bengsch B; Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Huang AC; Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Schenkel JM; Department of Medicine and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Vahedi G; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.
  • Haining WN; Department of Genetics and Institute for Immunology, University of Pennsylvania, Philadelphia, PA, USA.
  • Berger SL; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Wherry EJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Science ; 354(6316): 1160-1165, 2016 12 02.
Article in En | MEDLINE | ID: mdl-27789795
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Epigenesis, Genetic / Cellular Reprogramming / B7-H1 Antigen / Immunologic Memory Limits: Animals Language: En Journal: Science Year: 2016 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Epigenesis, Genetic / Cellular Reprogramming / B7-H1 Antigen / Immunologic Memory Limits: Animals Language: En Journal: Science Year: 2016 Document type: Article Affiliation country: United States Country of publication: United States