Comprehensive Characterization of Cellular Immune Responses Following Ebola Virus Infection.
J Infect Dis
; 215(2): 287-292, 2017 01 15.
Article
in En
| MEDLINE
| ID: mdl-27799354
ABSTRACT
The West African Ebola virus disease (EVD) outbreak was the largest EVD outbreak in history. However, data on lymphocyte dynamics and the antigen specificity of T cells in Ebola survivors are scarce, and our understanding of EVD pathophysiology is limited. A case of EVD survival in which the patient cleared Ebola virus (EBOV) infection without experimental drugs allowed for the detailed examination of lymphocyte dynamics. We demonstrate the persistence of T-cell activation well beyond viral clearance and detect EBOV-specific T cells. Our study provides significant insights into lymphocyte specificity during the recovery phase of EVD and may inform novel strategies to treat EVD.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hemorrhagic Fever, Ebola
/
Ebolavirus
/
Immunity, Cellular
Limits:
Humans
Language:
En
Journal:
J Infect Dis
Year:
2017
Document type:
Article