Exploring viral infection using single-cell sequencing.
Virus Res
; 239: 55-68, 2017 07 15.
Article
in En
| MEDLINE
| ID: mdl-27816430
ABSTRACT
Single-cell sequencing (SCS) has emerged as a valuable tool to study cellular heterogeneity in diverse fields, including virology. By studying the viral and cellular genome and/or transcriptome, the dynamics of viral infection can be investigated at single cell level. Most studies have explored the impact of cell-to-cell variation on the viral life cycle from the point of view of the virus, by analyzing viral sequences, and from the point of view of the cell, mainly by analyzing the cellular host transcriptome. In this review, we will focus on recent studies that use single-cell sequencing to explore viral diversity and cell variability in response to viral replication.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Virus Diseases
/
Virus Physiological Phenomena
/
Host-Pathogen Interactions
/
Single-Cell Analysis
/
High-Throughput Nucleotide Sequencing
Limits:
Animals
/
Humans
Language:
En
Journal:
Virus Res
Journal subject:
VIROLOGIA
Year:
2017
Document type:
Article