Significant contribution of TRPC6 channel-mediated Ca<sup>2+</sup> influx to the pathogenesis of Crohn's disease fibrotic stenosis.

Kurahara, Lin Hai; Hiraishi, Keizo; Sumiyoshi, Miho; Doi, Mayumi; Hu, Yaopeng; Aoyagi, Kunihiko; Jian, Yuwen; Inoue, Ryuji

Significant contribution of TRPC6 channel-mediated Ca²⁺ influx to the pathogenesis of Crohn's disease fibrotic stenosis.

Kurahara, Lin Hai; Hiraishi, Keizo; Sumiyoshi, Miho; Doi, Mayumi; Hu, Yaopeng; Aoyagi, Kunihiko; Jian, Yuwen; Inoue, Ryuji.

Affiliation

Kurahara LH; Department of Physiology, Fukuoka University School of Medicine, Fukuoka 814-0180, Japan.

J Smooth Muscle Res ; 52(0): 78-92, 2016.

Article in En | MEDLINE | ID: mdl-27818466

Subject(s)

Calcium/metabolism; Crohn Disease/etiology; Intestinal Obstruction/etiology; Intestines/pathology; TRPC Cation Channels/physiology; Crohn Disease/drug therapy; Crohn Disease/pathology; Extracellular Matrix/metabolism; Fibroblasts/physiology; Fibrosis; Humans; Intestines/cytology; Molecular Targeted Therapy; Myofibroblasts/physiology; Signal Transduction/physiology; TRPC6 Cation Channel; Transforming Growth Factor beta1/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crohn Disease / Calcium / TRPC Cation Channels / Intestinal Obstruction / Intestines Type of study: Etiology_studies Limits: Humans Language: En Journal: J Smooth Muscle Res Journal subject: FISIOLOGIA Year: 2016 Document type: Article Affiliation country: Japan Country of publication: Japan

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