TLR signalling and association of TLR polymorphism with cardiovascular diseases.
Vascul Pharmacol
; 87: 30-37, 2016 12.
Article
in En
| MEDLINE
| ID: mdl-27826031
ABSTRACT
Toll-Like receptors (TLRs) are the primary receptors of innate immunity. Considerable evidences have shown that innate immune defence interaction with pro-inflammatory pathways could be through TLRs that in turn leads to development of inflammatory diseases. These TLRs are present on various tissues and cells of cardiovascular system. Previous studies involving SNPs analysis of TLRs demonstrated that TLRs are involved in development and progression of diseases like atherosclerosis, cardiac dysfunction in sepsis and congestive heart failure. In this review, we aimed to bring together the studies which have been conducted previously to establish a link between TLR polymorphism in context to development of cardiovascular diseases (CVD).
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cardiovascular Diseases
/
Toll-Like Receptors
/
Inflammation
Type of study:
Risk_factors_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Vascul Pharmacol
Journal subject:
ANGIOLOGIA
/
FARMACOLOGIA
Year:
2016
Document type:
Article
Affiliation country:
India