Acute interstitial nephritis related to immune checkpoint inhibitors.
Br J Cancer
; 115(12): 1457-1461, 2016 Dec 06.
Article
in En
| MEDLINE
| ID: mdl-27832664
ABSTRACT
BACKGROUND:
Immune checkpoint inhibitors (anti-PD1 or anti-CTLA-4) are increasingly used in various cancers. Immune checkpoint inhibitors (ICI)-related renal disorders are poorly described (9 cases) and were only related to Ipilimumab.METHODS:
Retrospective collection of clinical charts of all the patients admitted for renal disorders following ICI in the University Hospital of Toulouse (France).RESULTS:
We report on adverse renal events that occurred in three patients treated with anti-PD1 (nivolumab or pembrolizumab) or anti-CTLA-4 (ipilimumab). Acute kidney injury occurred at 4-12 weeks after initiation of treatment, and harbored features of tubulo-interstitial nephritis (interstitial polymorphic inflammatory infiltrate with predominant CD3+ CD4+ T cells, associated with granuloma in one). Following withdrawal of ICI and steroid intake, estimated glomerular-filtration rate had improved in all patients.CONCLUSIONS:
These data suggest that all ICI can lead to acute interstitial nephritis, possibly related to the presence of autoreactive clonal T cells. We recommend that patients receiving ICI should undergo renal monitoring every 2 weeks for 3-6 months.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Cycle Checkpoints
/
Antibodies, Monoclonal
/
Nephritis, Interstitial
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Br J Cancer
Year:
2016
Document type:
Article
Affiliation country:
France