Naphthoquine-induced Central Nervous System and Hepatic Vasculocentric Toxicity in the Beagle Dog.

Galarneau, Jean-Rene; Meseck, Emily K; Hall, Robert L; Li, Wenkui; Weaver, Margaret L

Galarneau, Jean-Rene; Meseck, Emily K; Hall, Robert L; Li, Wenkui; Weaver, Margaret L.

Affiliation

Galarneau JR; 1 Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Meseck EK; 2 Covance Laboratories, Madison, Wisconsin, USA.
Hall RL; 3 Novartis Institutes for BioMedical Research, East Hanover, New Jersey, USA.
Li W; 2 Covance Laboratories, Madison, Wisconsin, USA.
Weaver ML; 3 Novartis Institutes for BioMedical Research, East Hanover, New Jersey, USA.

Toxicol Pathol ; 44(8): 1128-1136, 2016 12.

Article in En | MEDLINE | ID: mdl-27834287

Subject(s)

1-Naphthylamine/analogs & derivatives; Aminoquinolines/toxicity; Antimalarials/toxicity; Central Nervous System/drug effects; Liver/drug effects; Vasculitis/chemically induced; 1-Naphthylamine/toxicity; Aminoquinolines/blood; Animals; Antimalarials/blood; Central Nervous System/blood supply; Central Nervous System/pathology; Dogs; Dose-Response Relationship, Drug; Female; Immunohistochemistry; Liver/blood supply; Liver/pathology; Male; Toxicokinetics; Vasculitis/pathology

Key words

Plasmodium falciparum; hepatotoxicity; malaria; naphthoquine; neurotoxicity; toxicity; vasculocentric inflammation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vasculitis / Central Nervous System / Aminoquinolines / Liver / 1-Naphthylamine / Antimalarials Limits: Animals Language: En Journal: Toxicol Pathol Year: 2016 Document type: Article Affiliation country: United States

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