Selective sweep on human amylase genes postdates the split with Neanderthals.
Sci Rep
; 6: 37198, 2016 11 17.
Article
in En
| MEDLINE
| ID: mdl-27853181
ABSTRACT
Humans have more copies of amylase genes than other primates. It is still poorly understood, however, when the copy number expansion occurred and whether its spread was enhanced by selection. Here we assess amylase copy numbers in a global sample of 480 high coverage genomes and find that regions flanking the amylase locus show notable depression of genetic diversity both in African and non-African populations. Analysis of genetic variation in these regions supports the model of an early selective sweep in the human lineage after the split of humans from Neanderthals which led to the fixation of multiple copies of AMY1 in place of a single copy. We find evidence of multiple secondary losses of copy number with the highest frequency (52%) of a deletion of AMY2A and associated low copy number of AMY1 in Northeast Siberian populations whose diet has been low in starch content.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genetic Variation
/
Genome, Human
/
Gene Dosage
/
Evolution, Molecular
/
Amylases
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
En
Journal:
Sci Rep
Year:
2016
Document type:
Article
Affiliation country:
United kingdom