DNA topoisomerase I and DNA gyrase as targets for TB therapy.

Nagaraja, Valakunja; Godbole, Adwait A; Henderson, Sara R; Maxwell, Anthony

Nagaraja, Valakunja; Godbole, Adwait A; Henderson, Sara R; Maxwell, Anthony.

Affiliation

Nagaraja V; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560 012, India; Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India.
Godbole AA; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560 012, India.
Henderson SR; Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.
Maxwell A; Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address: tony.maxwell@jic.ac.uk.

Drug Discov Today ; 22(3): 510-518, 2017 03.

Article in En | MEDLINE | ID: mdl-27856347

Subject(s)

Bacterial Proteins/metabolism; DNA Gyrase/metabolism; DNA Topoisomerases, Type I/metabolism; Mycobacterium tuberculosis/enzymology; Tuberculosis/enzymology; Antitubercular Agents/pharmacology; Antitubercular Agents/therapeutic use; Bacterial Proteins/antagonists & inhibitors; DNA Cleavage; Humans; Mycobacterium tuberculosis/drug effects; Topoisomerase I Inhibitors/pharmacology; Topoisomerase I Inhibitors/therapeutic use; Topoisomerase II Inhibitors/pharmacology; Topoisomerase II Inhibitors/therapeutic use; Tuberculosis/drug therapy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Tuberculosis / DNA Topoisomerases, Type I / DNA Gyrase / Mycobacterium tuberculosis Limits: Humans Language: En Journal: Drug Discov Today Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2017 Document type: Article Affiliation country: India Country of publication: United kingdom

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