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Design and Synthesis of Selurampanel, a Novel Orally Active and Competitive AMPA Receptor Antagonist.
Orain, David; Tasdelen, Engin; Haessig, Samuel; Koller, Manuel; Picard, Anne; Dubois, Celine; Lingenhoehl, Kurt; Desrayaud, Sandrine; Floersheim, Phillip; Carcache, David; Urwyler, Stephan; Kallen, Joerg; Mattes, Henri.
Affiliation
  • Orain D; Global Discovery Chemistry, Novartis Institute for Biomedical Research, 4002, Basel, Switzerland.
  • Tasdelen E; Global Discovery Chemistry, Novartis Institute for Biomedical Research, 4002, Basel, Switzerland.
  • Haessig S; Global Discovery Chemistry, Novartis Institute for Biomedical Research, 4002, Basel, Switzerland.
  • Koller M; Global Discovery Chemistry, Novartis Institute for Biomedical Research, 4002, Basel, Switzerland.
  • Picard A; Global Discovery Chemistry, Novartis Institute for Biomedical Research, 4002, Basel, Switzerland.
  • Dubois C; Global Discovery Chemistry, Novartis Institute for Biomedical Research, 4002, Basel, Switzerland.
  • Lingenhoehl K; Previously: Neuroscience Disease Area, Novartis Institute for Biomedical Research, 4002, Basel, Switzerland.
  • Desrayaud S; Metabolism and Pharmacokinetics, Novartis Institute for Biomedical Research, 4002, Basel, Switzerland.
  • Floersheim P; Global Discovery Chemistry, Novartis Institute for Biomedical Research, 4002, Basel, Switzerland.
  • Carcache D; Global Discovery Chemistry, Novartis Institute for Biomedical Research, 4002, Basel, Switzerland.
  • Urwyler S; Previously: Neuroscience Disease Area, Novartis Institute for Biomedical Research, 4002, Basel, Switzerland.
  • Kallen J; Center for Proteomic Chemistry, Novartis Institute for Biomedical Research, 4002, Basel, Switzerland.
  • Mattes H; Global Discovery Chemistry, Novartis Institute for Biomedical Research, 4002, Basel, Switzerland.
ChemMedChem ; 12(3): 197-201, 2017 02 03.
Article in En | MEDLINE | ID: mdl-27863026
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Receptors, AMPA / Quinazolinones Limits: Animals Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2017 Document type: Article Affiliation country: Switzerland Country of publication: Germany
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Receptors, AMPA / Quinazolinones Limits: Animals Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2017 Document type: Article Affiliation country: Switzerland Country of publication: Germany