Serum and urinary biomarkers that predict hepatorenal syndrome in patients with advanced cirrhosis.
Dig Liver Dis
; 49(2): 202-206, 2017 Feb.
Article
in En
| MEDLINE
| ID: mdl-27876501
ABSTRACT
BACKGROUND:
Prediction of hepatorenal syndrome (HRS) remains difficult in advanced cirrhotic patients.AIMS:
To evaluate use of serum and urine biomarkers to predict HRS.METHODS:
We prospectively recruited Child's B or C cirrhotic patients with normal serum creatinine, and followed them for 12 weeks for the development of HRS. Serum Cystatin C (CysC), serum and urine Neutrophil Gelatinase-Associated Lipocalin (NGAL), serum and urine IL-18, serum N-acetyl-ß-d glucosaminidase (NAG), urine kidney injury molecule-1 (KIM-1) and urine liver-type fatty acid binding protein (LFABP) were measured at recruitment (baseline), and their relationship with subsequent HRS investigated.RESULTS:
43 patients were included. 12 (27.9%) developed HRS at 7.3±5.1 weeks from baseline. Logistic regression analysis showed that baseline urinary NGAL and urinary KIM-1 were significantly associated with the development of HRS (RR 1.007, 95% CI 1.001-1.012, p=0.014; RR 1.973, 95% CI 1.002-3.886, p=0.049). The cut-off values for NGAL and KIM-1 to predict HRS were 18.72ng/mL and 1.499ng/mL respectively (AUCs 0.84, p=0.005; and 0.78, p=0.008).CONCLUSION:
Urinary NGAL and KIM-1 could serve as biomarkers to predict HRS in advanced cirrhotic patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hepatorenal Syndrome
/
Biomarkers
/
Liver Cirrhosis
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Dig Liver Dis
Journal subject:
GASTROENTEROLOGIA
Year:
2017
Document type:
Article