Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota.

Josefsdottir, Kamilla S; Baldridge, Megan T; Kadmon, Claudine S; King, Katherine Y

Josefsdottir, Kamilla S; Baldridge, Megan T; Kadmon, Claudine S; King, Katherine Y.

Affiliation

Josefsdottir KS; Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX; and.
Baldridge MT; Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO.
Kadmon CS; Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX; and.
King KY; Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX; and.

Blood ; 129(6): 729-739, 2017 02 09.

Article in En | MEDLINE | ID: mdl-27879260

Subject(s)

Anemia/chemically induced; Anti-Bacterial Agents/adverse effects; Gastrointestinal Microbiome/drug effects; Hematopoiesis/drug effects; Leukopenia/chemically induced; STAT1 Transcription Factor/genetics; Thrombocytosis/chemically induced; Anemia/microbiology; Anemia/pathology; Anemia/therapy; Animals; B-Lymphocytes/drug effects; B-Lymphocytes/metabolism; B-Lymphocytes/pathology; Bone Marrow Cells/drug effects; Bone Marrow Cells/metabolism; Bone Marrow Cells/pathology; CD8-Positive T-Lymphocytes/drug effects; CD8-Positive T-Lymphocytes/metabolism; CD8-Positive T-Lymphocytes/pathology; Fecal Microbiota Transplantation; Gastrointestinal Microbiome/physiology; Gene Expression; Germ-Free Life/drug effects; Germ-Free Life/genetics; Granulocytes/drug effects; Granulocytes/metabolism; Granulocytes/pathology; Hematopoiesis/genetics; Hematopoietic Stem Cells/drug effects; Hematopoietic Stem Cells/metabolism; Hematopoietic Stem Cells/pathology; Leukopenia/microbiology; Leukopenia/pathology; Leukopenia/therapy; Macrophages/drug effects; Macrophages/metabolism; Macrophages/pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; STAT1 Transcription Factor/deficiency; Signal Transduction; Thrombocytosis/microbiology; Thrombocytosis/pathology; Thrombocytosis/therapy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombocytosis / STAT1 Transcription Factor / Gastrointestinal Microbiome / Hematopoiesis / Anemia / Leukopenia / Anti-Bacterial Agents Type of study: Prognostic_studies Language: En Journal: Blood Year: 2017 Document type: Article

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