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Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine.
Albany, Costantine; Hever-Jardine, Mary P; von Herrmann, Katherine M; Yim, Christina Y; Tam, Janice; Warzecha, Joshua M; Shin, Leah; Bock, Sarah E; Curran, Brian S; Chaudhry, Aneeq S; Kim, Fred; Sandusky, George E; Taverna, Pietro; Freemantle, Sarah J; Christensen, Brock C; Einhorn, Lawrence H; Spinella, Michael J.
Affiliation
  • Albany C; Division of Hematology/Oncology, Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Hever-Jardine MP; Departments of Pharmacology and Toxicology and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
  • von Herrmann KM; Departments of Pharmacology and Toxicology and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
  • Yim CY; Departments of Pharmacology and Toxicology and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
  • Tam J; Departments of Pharmacology and Toxicology and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
  • Warzecha JM; Departments of Pharmacology and Toxicology and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
  • Shin L; Departments of Pharmacology and Toxicology and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
  • Bock SE; Departments of Pharmacology and Toxicology and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
  • Curran BS; Departments of Pharmacology and Toxicology and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
  • Chaudhry AS; Departments of Pharmacology and Toxicology and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
  • Kim F; Departments of Pharmacology and Toxicology and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
  • Sandusky GE; Department of Pathology, Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Taverna P; Astex Pharmaceutical, Pleasanton, CA, USA.
  • Freemantle SJ; Department of Comparative Biosciences, The University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Christensen BC; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
  • Einhorn LH; Division of Hematology/Oncology, Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Spinella MJ; Department of Comparative Biosciences, The University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Oncotarget ; 8(2): 2949-2959, 2017 Jan 10.
Article in En | MEDLINE | ID: mdl-27936464
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azacitidine / Testicular Neoplasms / Neoplasms, Germ Cell and Embryonal / Drug Resistance, Neoplasm / DNA Methylation / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Oncotarget Year: 2017 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azacitidine / Testicular Neoplasms / Neoplasms, Germ Cell and Embryonal / Drug Resistance, Neoplasm / DNA Methylation / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Oncotarget Year: 2017 Document type: Article Affiliation country: United States Country of publication: United States