A hamster model for Marburg virus infection accurately recapitulates Marburg hemorrhagic fever.
Sci Rep
; 6: 39214, 2016 12 15.
Article
in En
| MEDLINE
| ID: mdl-27976688
ABSTRACT
Marburg virus (MARV), a close relative of Ebola virus, is the causative agent of a severe human disease known as Marburg hemorrhagic fever (MHF). No licensed vaccine or therapeutic exists to treat MHF, and MARV is therefore classified as a Tier 1 select agent and a category A bioterrorism agent. In order to develop countermeasures against this severe disease, animal models that accurately recapitulate human disease are required. Here we describe the development of a novel, uniformly lethal Syrian golden hamster model of MHF using a hamster-adapted MARV variant Angola. Remarkably, this model displayed almost all of the clinical features of MHF seen in humans and non-human primates, including coagulation abnormalities, hemorrhagic manifestations, petechial rash, and a severely dysregulated immune response. This MHF hamster model represents a powerful tool for further dissecting MARV pathogenesis and accelerating the development of effective medical countermeasures against human MHF.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Marburgvirus
/
Marburg Virus Disease
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Sci Rep
Year:
2016
Document type:
Article
Affiliation country:
United States