Copper-Catalyzed Regioselective Ring-Opening Hydroamination of Methylenecyclopropanes.
J Org Chem
; 81(24): 12128-12134, 2016 12 16.
Article
in En
| MEDLINE
| ID: mdl-27978715
ABSTRACT
A copper-catalyzed ring-opening hydroamination of methylenecyclopropanes with polymethylhydrosiloxane and O-benzoylhydroxylamines has been developed. The cyclopropane C-C bond cleavage occurs selectively at the more congested proximal position, and the corresponding homoallylamines are obtained in good to excellent yields. The umpolung electrophilic amination strategy with the hydroxylamine derivatives can provide a new reaction mode of methylenecyclopropanes in the catalytic hydroamination reaction.
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Org Chem
Year:
2016
Document type:
Article
Affiliation country:
Japan