Effect of alprazolam on ischemia and reperfusion-induced ventricular arrhythmias in the isolated perfused rat heart.
Pharmacology
; 39(2): 129-36, 1989.
Article
in En
| MEDLINE
| ID: mdl-2798552
ABSTRACT
The effects of the triazolobenzodiazepine anxiolytic, alprazolam, on the incidence of ischemia- and reperfusion-induced ventricular arrhythmias was studied in the isolated buffer-perfused rat heart. Administration of alprazolam before and after myocardial ischemia resulted in a dosage-dependent reduction in the incidence and duration of reperfusion-induced ventricular fibrillation and was significant at a concentration of 1 X 10(-3) mol/l alprazolam. This cardioprotective effect was not extended to ischemia-induced ventricular dysrhythmias. In conclusion, our findings provide evidence that benzodiazepine drugs are able to provide a cardioprotective effect in the experimental setting of myocardial ischemia followed by coronary reperfusion.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arrhythmias, Cardiac
/
Alprazolam
/
Myocardial Reperfusion Injury
/
Coronary Disease
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
Pharmacology
Year:
1989
Document type:
Article
Affiliation country:
Canada
Publication country:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND