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Early pancreatic cancer lesions suppress pain through CXCL12-mediated chemoattraction of Schwann cells.
Demir, Ihsan Ekin; Kujundzic, Kristina; Pfitzinger, Paulo L; Saricaoglu, Ömer Cemil; Teller, Steffen; Kehl, Timo; Reyes, Carmen Mota; Ertl, Linda S; Miao, Zhenhua; Schall, Thomas J; Tieftrunk, Elke; Haller, Bernhard; Diakopoulos, Kalliope Nina; Kurkowski, Magdalena U; Lesina, Marina; Krüger, Achim; Algül, Hana; Friess, Helmut; Ceyhan, Güralp O.
Affiliation
  • Demir IE; Department of Surgery, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany; ekin.demir@tum.de gueralp.ceyhan@tum.de.
  • Kujundzic K; Department of Surgery, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Pfitzinger PL; Department of Surgery, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Saricaoglu ÖC; Department of Surgery, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Teller S; Department of Surgery, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Kehl T; Department of Surgery, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Reyes CM; Department of Surgery, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Ertl LS; ChemoCentryx, Inc., Mountain View, CA 94043.
  • Miao Z; ChemoCentryx, Inc., Mountain View, CA 94043.
  • Schall TJ; ChemoCentryx, Inc., Mountain View, CA 94043.
  • Tieftrunk E; Department of Surgery, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Haller B; Institute of Medical Statistics and Epidemiology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Diakopoulos KN; Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Kurkowski MU; Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Lesina M; Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Krüger A; Institute for Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Algül H; Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Friess H; Department of Surgery, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Ceyhan GO; Department of Surgery, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany; ekin.demir@tum.de gueralp.ceyhan@tum.de.
Proc Natl Acad Sci U S A ; 114(1): E85-E94, 2017 01 03.
Article in En | MEDLINE | ID: mdl-27986950
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Pancreatic Neoplasms / Schwann Cells / Chemotaxis / Receptors, CXCR4 / Carcinoma, Pancreatic Ductal / Chemokine CXCL12 / Receptors, CXCR Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2017 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Pancreatic Neoplasms / Schwann Cells / Chemotaxis / Receptors, CXCR4 / Carcinoma, Pancreatic Ductal / Chemokine CXCL12 / Receptors, CXCR Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2017 Document type: Article Country of publication: United States