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Metabolism and Disposition of a Novel B-Cell Lymphoma-2 Inhibitor Venetoclax in Humans and Characterization of Its Unusual Metabolites.
Liu, Hong; Michmerhuizen, Melissa J; Lao, Yanbin; Wan, Katty; Salem, Ahmed Hamed; Sawicki, James; Serby, Michael; Vaidyanathan, Srirajan; Wong, Shekman L; Agarwal, Suresh; Dunbar, Martin; Sydor, Jens; de Morais, Sonia M; Lee, Anthony J.
Affiliation
  • Liu H; Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Sh
  • Michmerhuizen MJ; Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Sh
  • Lao Y; Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Sh
  • Wan K; Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Sh
  • Salem AH; Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Sh
  • Sawicki J; Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Sh
  • Serby M; Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Sh
  • Vaidyanathan S; Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Sh
  • Wong SL; Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Sh
  • Agarwal S; Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Sh
  • Dunbar M; Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Sh
  • Sydor J; Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Sh
  • de Morais SM; Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Sh
  • Lee AJ; Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Sh
Drug Metab Dispos ; 45(3): 294-305, 2017 03.
Article in En | MEDLINE | ID: mdl-27993930
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Bridged Bicyclo Compounds, Heterocyclic / Proto-Oncogene Proteins c-bcl-2 / Antineoplastic Agents Limits: Female / Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2017 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Bridged Bicyclo Compounds, Heterocyclic / Proto-Oncogene Proteins c-bcl-2 / Antineoplastic Agents Limits: Female / Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2017 Document type: Article